Microdosing GLP-1s: What the Science Actually Says

The Trend: Microdosing is the most recent take on GLP-1s. Instead of the standard weekly dose, some people are taking smaller amounts (sometimes by “counting clicks” on the injection pen) in hopes of avoiding side effects or getting benefits beyond weight loss, like improved heart health or reduced inflammation. The trend has taken off mainly via social media influencers and a handful of physicians who support the practice.

What People Are Saying: Some influencers and physicians contend that microdosing makes for a “gentler” GLP-1 experience, having noticed fewer digestive issues than with the full dose. Some doctors also note microdosing can have anti-inflammatory benefits, including potential relief for conditions like psoriasis. Big names like Tufts Medicine and the American Diabetes Association aren’t endorsing microdosing though. There are no trials comparing microdosing to FDA-approved dosing, and these lower doses don’t consistently provide the same cardiovascular or metabolic benefits.

What to Know: Microdosing GLP-1s is experimental and most feedback on the regimen is anecdotal. The mild side effects people have reported aren’t guaranteed, and even small doses of a GLP-1 can still slow digestion. Microdosing is not backed by research, but if you’re still interested, speak with a doctor for guidance.