Do “Forever Chemicals” Speed Up Aging?

Forever-ever?: Another day, more not-great news about “forever” PFAS chemicals. New research published in the journal Frontiers in Aging has linked two of these chemicals to accelerated aging at the cellular level in men over 50. 

The Study: Researchers pulled data from 326 randomly chosen U.S. adult men and women in the 1999–2000 National Health and Nutrition Examination Survey (NHANES), all over age 50. They also analyzed blood samples that had been gathered during the NHANES study. Two chemicals in particular — PFNA and PFOSA — were found in 95% of the participants. The researchers then ran their DNA through epigenetic “clocks” to estimate their biological aging. 

The Takeaway: These chemicals were associated with two to four years of accelerated epigenetic aging — most significantly in men ages 50 to 64. The same effect wasn’t seen in women, which researchers hypothesized could be attributed to hormonal and lifestyle differences. PFNA can be found in nonstick cookware, waterproof materials, water, and soil. PFOSA is commonly used to coat food packaging to repel water and grease. (Here are three ways to reduce your exposure.)

Keep in Mind: The study did not prove causation, but it certainly adds texture to our understanding of the risks PFAS may present to our health.