Researchers Found a Way to “Wake Up” Aging Immune Cells

Immunity Boost: It might still be the dog days of summer right now, but it’s never too early to start thinking about immunity as fall and winter sick seasons approach — especially if you have littles or elders at home. For the latter group, scientists may have discovered a way to “wake up” tired immune cells that allows them to behave like younger immune cells, potentially boosting their protective factor. 

The Study: Scientists developed tiny silicon nanowires coated with polyethyleneimine (a synthetic polymer) to deliver microRNAs (miRNAs) directly into aging T cells. These molecules help regulate the genetic programs that control how T cells activate, multiply, metabolize energy, and develop into immune-fighting cells. The researchers found that delivering multiple miRNAs produced broader benefits than using a single molecule, boosting T-cell activation, multiplication, and activity. In experiments involving mice and human cells from older donors, the treatment improved the cells’ ability to respond to immune challenges and showed potential for boosting their ability to fight cancer.

Takeaway: Delivering miRNA into aging immune cells may help reinvigorate them, pointing toward a future in which they could be functionally reprogrammed.

Keep in Mind: This research is still highly experimental, and the effects of the treatment only lasted about two weeks, but it’s a promising finding.